Unit dose sampling (UDS)

Unit dose sampling (UDS) is a method commonly applied in pharmaceutical production. The target is to proof the „Content Uniformity“ of mixtures. Content Uniformity means the homogenous distribution of the components within a mixture. The examination method that is also called Blend Uniformity Analysis (BUA) is described in the FDA or GMP guidelines.
Since this procedure has to proof the content uniformity for the smallest applicable dose the quantity of the withdrawn sample must not exceed 1-3 times of this quantity.
Taking of such small and at the same time representative samples is enormously difficult, since the introduction and moving instruments can already lead to separation. The different portions of a mixture can have different detention and flow characteristics and this can lead to the fact that the sample is no longer representative.
It is therefore important to accomplish this particularly delicate sampling procedure correctly and to know the extent of the separation. In any case it is to be validated for the respective application or the respective product. The construction and function mode of the following UDS samplers are optimized to minimize the measurable separation effect.

All items marked "UDS" or "UD" / "U-D" are suitable for Unit Dose Sampling. Please choose a product from the list on the left side to see the description.

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